Cytotoxic T lymphocyte-associated antigen-4 inhibits integrin-mediated stimulation
نویسندگان
چکیده
منابع مشابه
Cytotoxic T-lymphocyte-associated antigen-4.
Cancer immunotherapy relies on the ability of the immune system to target tumor-specific antigens to generate an immune response. This initial response requires both binding of the MHC/antigen peptide to T-cell receptor complex, along with a second costimulatory signal created by the binding of CD28 on the T cell, with B7 located on the antigen-presenting cell. Regulatory checkpoints, such as c...
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Approaches aimed at enhancement of the tumor specific response have provided proof for the rationale of immunotherapy in cancer, both in animal models and in humans. Ipilimumab, an anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) antibody, is a new generation immunotherapeutic agent that has shown activity in terms of disease free and overall survival in metastatic melanoma patients. Its use was ...
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ژورنال
عنوان ژورنال: Immunology
سال: 2002
ISSN: 0019-2805,1365-2567
DOI: 10.1046/j.1365-2567.2002.01493.x